Shanghai Chematis Co.,Ltd.

Arbidol hydrochloride having carboxylic acid ester structure and may be a carrier pro-drug. Structure of this drug is mostly lipophilic. As the hydrolysis substrate, it is subject to simple in vivo hydrolysis and the carrier is removed. It then forms active compound and accumulates in the cells, ultimately playing its pharmacological role. The mechanism of action of Arbidol hydrochloride is through activating Arbidol hydrochloride 2,5-oligoadenylate synthetase and specifically preventing the contact, adhesion and fusion between influenza virus envelope with the host cell membrane, thereby blocking the replication of influenza virus, and can penetrate the nucleus to directly inhibit the viral RNA and DNA synthesis; on the other hand, it has immunomodulatory, interferon-induction and antioxidant properties. It is able to stimulate the host cells to produce interferon and stimulate humoral response and phagocytosis of macrophages, causing cellular and humoral immunity, suggesting that its anti-viral effect is closely related to improving the immune function. Anti-infection mechanisms: acidic condition (pH 5.0) is the necessary condition for influenza virus-mediated fusion with a slight increase in pH being capable of preventing the fusion process. Water soluble arbidol is a weak alkaline drug and is capable of increasing the pH of cytoplasm of the host cells so that the virus can not complete the process of membrane fusion for release of the viral genome which effectively suppresses the acute and chronic infection caused by HCV belonging to the Orthomyxoviridae.